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M9480006.TXT
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1994-08-09
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Document 0006
DOCN M9480006
TI Placental cryptococcosis in a mother with systemic lupus erythematosus.
DT 9410
AU Molnar-Nadasdy G; Haesly I; Reed J; Altshuler G; Department of
Pathology, University of Oklahoma Health Sciences; Center, Oklahoma
City.
SO Arch Pathol Lab Med. 1994 Jul;118(7):757-9. Unique Identifier : AIDSLINE
MED/94296232
AB There are many pregnant mothers who have acquired immunodeficiency
syndrome or who require immunosuppressive therapy for sundry reasons.
Despite this, we have been able to find only one English-language report
of placental cryptococcosis. We have had an opportunity to treat a
pregnant mother who suffered from cryptococcal meningitis that
complicated steroid treatment for lupus erythematosus. At 31 weeks'
gestation, fetal distress necessitated delivery by cesarean section. The
placenta had focally abundant intervillous and perivillous cryptococcal
yeast cells, but there was no chorioamnionitis or villitis. Although
there were no clinical or placental signs of transplacental infection,
immunohistochemical labeling of villous stromal cells showed a
conspicuously increased number of fetal macrophages.
DE Adult Case Report Cryptococcosis/IMMUNOLOGY/*PATHOLOGY Female Human
Immunosuppressive Agents/THERAPEUTIC USE Lupus Erythematosus,
Systemic/*COMPLICATIONS/DRUG THERAPY Meningitis,
Cryptococcal/COMPLICATIONS Opportunistic Infections/PATHOLOGY Placenta
Diseases/*MICROBIOLOGY/PATHOLOGY Pregnancy *Pregnancy Complications
Pregnancy Complications, Infectious/MICROBIOLOGY/*PATHOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).